P-glycoprotein removes Alzheimer’s-associated toxin from the brain


Lauren Ammerman and James McCormick, who are getting married in November, sought to do research on Alzheimer's disease after both SMU graduate students lost a grandmother to the disease.
(A) The first frame of SMU's simulation shows amyloid-β bound to the drug binding domains of P-gp. (B) The final frame of the same simulation shows P-gp pushing an amyloid protein through the cell membrane to outside the cell.