Chemistry Faculty & Staff

Alex Lippert

Professor Alex Lippert

Assistant Professor Office:  141 Fondren Science 
Department of Chemistry  Phone:  (214) 768-2482 
Southern Methodist University  Fax: (214) 768-4089
PO Box 750314 e-mail:
Dallas, TX 75275-0314    

[Research Group Site]


  • Assistant Professor, Southern Methodist University, 2012
  • Postdoc, University of California, Berkeley, 2009-2012
  • Ph.D. University of Pennsylvania, 2008
  • B.S. Caltech, 2003

Research Interests:

The Lippert lab combines innovative organic chemistry with state-of-the-art imaging techniques. We synthesize biocompatible dyes and MRI contrast agents that are activated by chemical reactions inside of cells, enabling the real-time tracking of biochemical events in living systems. These newly developed probes will provide unique tools to study cellular chemistry important in cancer, cardiovascular disease, and neuronal signaling.

Selected Publications:
  1. Lin, V. A.; Lippert, A. R.; Chang, C. J. "Cell-trappable fluorescent probes for endogenous hydrogen sulfide signaling: Imaging H2O2-dependent H2S production." Proc. Natl. Acad. Sci. USA 2013, 110, 7131-7135. (Highlighted in the April 22 issue of Chemical & Engineering News)
  2. Michel, B. W.; Lippert, A. R.; Chang, C. J. "A Reaction-Based Fluorescent Probe for Selective Imaging of Carbon Monoxide in Living Cells Using a Palladium-Mediated Carbonylation." J. Am. Chem. Soc. 2012, 124, 15668-15671.
  3. Lippert, A. R.; Van De Bittner, G. C.; Chang, C. J. "Coronate Oxidation as a Bioorthogonal Reaction Approach for Studying the Chemistry of Hydrogen Peroxide in Living Systems." Acc. Chem. Res. 2011, 47, 793.
  4. Lippert, A. R.; New, E. J.; Chang, C. J. "Reaction-Based Fluorescent Probes for the Selective Imaging of Hydrogen Sulfide in Living Cells." J. Am. Chem. Soc. 2011, 133, 10078. (Highlighted in the October 17 issue of Chemical & Engineering News)
  5. Lippert, A. R.; Keshari, K. R.; Kurhanewicz, J.; Chang, C. J. "A Hydrogen Peroxide Responsive Hyperpolarized 13C MRI Contrast Agent." J. Am. Chem. Soc. 2011, 133, 3776.
  6. Lippert, A. R.; Naganawa, A.; Keleshian, V. L.; Bode, J. W. "Synthesis of Phototrappable Shapeshifting Molecules for Adaptive Guest Binding." J. Am. Chem. Soc. 2010, 132, 15790.
  7. Lippert, A. R.; Gschneidtner, T.; Chang, C. J. "Lanthanide-Based Luminescent Probes for Selective Time-Gated Detection of Hydrogen Peroxide in Water and Living Cells." Chem. Commun. 2010, 46, 7510.
  8. Ju, L.; Lippert, A. R.; Bode, J. W. "Sterepretentive Synthesis and Chemoselective Amide-Forming Ligations of C- Terminal Peptide α-Ketoacides." Org. Biomol. Chem. 2008, 130, 4253.