• Introduction
• Undergraduate
• Graduate
• Faculty & Staff
• Research
• Courses
• Seminars
• Contact Us
• 2008 Newsletter
• 2008 MIM

	John D. Buynak
	Professor	Office:	311 Fondren Science
	Department of Chemistry	Phone:	(214) 768-2484
	Southern Methodist University	Fax:	(214) 768-4089
	PO Box 750314	e-mail:
	Dallas, TX 75275-0314
	| Prof. Buynak's Home Page |

Education:

• Ph.D. Rice University, 1980

Bioorganic chemistry, medicinal chemistry, design of enzyme inhibitors, synthesis of beta-lactam antibiotics and beta-lactamase inhibitors.

• Buynak, J. D. "Cutting and Stitching: the Cross-Linking of Peptidoglycan in the Assembly of the Bacterial Cell Wall." ACS Chemical Biology 2007, 2, 602-605.

• Kalp, M.; Sheri, A.; Buynak, J. D.; Bethel, C. R.; Bonomo, R. A. Carey, P. R. "Efficient Inhibition of Class A and Class D b-Lactamases by Michaelis Complexes." Journal of Biological Chemistry 2007, 282, 21588-21591.

• Buynak, J. D.; Chen, H. "Cephalosporin-derived mercaptans as inhibitors of serine and metallo-b-lactamases. U. S. Patent 2006, US 2006178357 A1 200660810.

• Padayatti, P. S.; Sheri, A.; Totir, M. A.; Helfand, M. S.; Carey, M. P.; Anderson, V. E.; Carey, P. R.; Bethel, C. R.; Bonomo, R. A.; Buynak, J. D.; van den Akker, F. "Rational Design of a b-Lactamase Inhibitor Achieved via Stabilization of the trans-Enamine Intermediate: 1.28 Å Crystal Structure of wt SHV-1 with a Penam Sulfone.  Journal of the American Chemical Society 2006, 128, 13235-13242.

• Buynak, John D.  “Understanding the longevity of the b-lactam antibiotics and of antibiotic/b-lactamase inhibitor combinations.”    Biochemical Pharmacology  2006,  71,  930-940. 

• Zhu, D.; Yang, Y.; Buynak, J. D.; Hua, L. "Stereoselective ketone reduction by a carbonyl reductase from Sporobolomyces salmonicolor.  Substrate specificity, enantioselectivity and enzyme-substrate docking studies." Organic and Biomolecular Chemistry 2006, 4, 2690-2695.

• Buynak, John D.; Ghadhachanda, Venkat R; Vogeti, Lakshminarayana; Zhang, H.; Chen, H. "Synthesis and Evaluation of 3-(Carboxymethylidene)- and 3-(Carboxymethyl)penicillinates as Inhibitors of b-Lactamase" Journal of Organic Chemistry 2005, 70, 4510-4513.

• Hujer, A. M.; Kania, M.; Gerken, T.; Anderson, V. E.; Buynak, J.; Ge, X.; Caspers, P.; Page, M. G. P.; Rice, L. B.; Bonomo, R. A. "Structure-Activity Relationships of Different b-Lactam Antibiotics against a Soluble Form of Enterococcus faecium PBP5, a Type II Bacterial Transpeptidase"  Antimicrobial Agents and Chemotherapy 2005, 49, 612-618.

• Buynak, J. D.; Chen H., Vogeti, L.; Gadhachanda, V. R.; Buchanan, C. A.; Palzkill, T.; Shaw, R. W.; Spencer, J.; Walsh, T. R. "Penicillin-derived Inhibitors that simultaneously target both metallo- and serine-b-Lactamases" Bioorganic & Medicinal Chemistry Letters 2004, 14(5), 1299-1304.

• Buynak, John D.  "The discovery and development of modified penicillin- and cephalosporin-derived b-Lactamase inhibitors."    Current Medicinal Chemistry  2004,  11,  1951-1964.

• Buynak, J. D.; Vogeti, L.; Chen, H. “Coupling Reactions of Cephalosporin Sulfones: a Stable 3-Stannylated Cephem” Organic Letters 2001, 3, 2953-2956.

• Crichlow, G. V.; Michiyoshi, N.; Doppalapudi, V. R.; Buynak, J. D.; Knox, J. R. “Inhibition of class C b-Lactamases: Structure of a Reaction Intermediate with a Cephem Sulfone” Biochemistry 2001, 40, 6233-6239.